Hemoglobin A1c Levels andMortality in the Diabetic Hemodialysis Population Findings from the Dialysis Outcomes and Practice Patterns Study (DOPPS)

RESULTSdThe association between A1c and mortality was U-shaped. Compared with an A1c of 7–7.9%, the hazard ratios (95%CI) for A1c levels were 1.35 (1.09–1.67) for,5%, 1.18 (1.01– 1.37) for 5–5.9%, 1.21 (1.05–1.41) for 6–6.9%, 1.16 (0.94–1.43) for 8–8.9%, and 1.38 (1.11– 1.71) for$9.0%, after adjustment for age, sex, race, BMI, serum albumin, years of dialysis, serum creatinine, 12 comorbid conditions, insulin use, hemoglobin, LDL cholesterol, country, and study phase. Diabetes medications were prescribed for 35% of patients with A1c ,6% and not prescribed for 29% of those with A1c $9%.